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The report on application Modafinil for treatment of dependence for Cocaine has been submitted Charles A. Dackis, MD, (Department of Psychiatry, University of Pennsylvania) at annual 156-th Congress of the American Psychiatric Association in May, 2003.
The large research directed on search of an optimum way of pharmacological treatment of dependence on Cocaine has been undertaken. Agonists and antagonists of Dopaminum, antidepressants, and also preparations belonging to other classes were earlier investigated, however unequivocal proofs of their efficiency has not been found.
Modafinil, in opinion of researchers, represents a preparation which is not having stimulating action [though in some sources the opposite data] which is applied to treatment of attacks of a sleepiness in the afternoon, observed contain at a narcolepsy. This preparation is characterized by the minimal by-effects and has no potential at patients with dependence on Cocaine.
Modafinil operates mainly through system and raises a level of synthesis of an acid. The basic signs of a cancellation of Cocaine are the sleepiness, a flaccidity, the reduced mood. In researches with participation of the patients, suffering a narcolepsy, application Modafinil has allowed to lower a sleepiness in the afternoon, to achieve improvement of mood, concentration and to raise a level of activity and sensation of well-being.
Dr. Dackis in the report has informed about series of the unpublished researches of application Modafinil which is carried outby its group at university of Pennsylvania.
In the first research interaction Modafinil and Cocaine was studied. Researched receiving Modafinil in a dose of 200-400 mg Cocaine was intravenously entered, and then them investigated for presence of bent for to reception of Cocaine, effects from its reception (euphoria); physical research and cardiac telemetry was carried out also. Any toxic interactions it has not been registered; reception Modafinil blocked separate displays of effects of reception of Cocaine (attributes of rising of a metabolism, euphoria).
The second research proceeded 8 weeks and has been directed on studying of an opportunity of therapy of dependence on Cocaine Modafinil. 17 patients who except for medicamental treatment twice a week received therapy participated in research. At all researched dependence was serious to what high doses of Cocaine and an expressiveness of "discomfortable" sensations in a condition of a cancellation testify. The received data were compared to control плацебо-group of similar research of medicamental treatment of dependence on Cocaine.
Remained in research of 70 % of patients from group Modafinil and 44 % of плацебо-group. Negative analyses of urine on the maintenance of Cocaine were at 47 % of members of group Modafinil and only at 6.5 % of members of control group. In interrogation members of group Modafinil informed downstroke of a level of depression and bent for to the use of Cocaine. It was not informed serious by-effects though there were indicatings on a sleeplessness and excessive activity for some patients. Thus, it is represented to researchers Modafinil by rather promising preparation for treatment of dependence for Cocaine. Nevertheless, for confirmation of preliminary results carrying out of double blind плацебо-controllable research is necessary.
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